Well, I think that the advice here and in your other thread sounds good.
IMO the ice-based hybrid route is pretty easy. Your goal is to survive until you get freezing cloud online, then that's it for 3-runes and it leads nicely into ice storm for the late game or more runes...
I like starting as a wizard, since you've got lots of other options for when things go wrong (meph cloud, summon imp, blink). And, since you cannot just tank things so much as you're used to, be forewarned that they will go wrong and you'll need those escape options.
I like polearms, since they're great for poking away at stuff while it has to sit in your freezing/flaming/toxic cloud. So a MfIE always seemed nice, especially with their swimming ability. Similarly for undead/Nagas and poisonous or mephitic clouds.
Arrows can work well for the same ranged damage through clouds idea, although management gets tedious.
To guarantee that you get the right spells, I'd suggest Vehumet, but if you're lucky with books, then Mahkleb works well, since he replaces the extra HP you lose in melee.
I like hybrids, but often get bored with and then kill off characters who don't have something to catch my attention. Both of my 15-rune wins were with DS (essentially ice-based hybrids). The reason for that, I think, is that the mutations hold my interest; not just that if you get a strong set of mutations, things get easy. I do best when I play into the strengths of the mutation: Extra HP, spines, freezing, or lifestealer, for example would be great for a hybrid; but there's a chance that a bad set could force you into the stealth/stabber path. DS work well as hybrids as you'll start to get mutations at just about the point where the diluted skills of a hybrid class will really hurt the most.
For DS, I often throw in a bit of necromancy for regeneration/sublimation, and later earth to shatter into vaults. Earth is also strong against things like bone dragons, so I suppose a DDEE might suit your purpose in an unusual way.
As too many of my successful characters were ice-based, currently I am trying to get a HOFE started for pretty much the same beefy hybrid you want. They've got good fire, fighting, and axe aptitudes so they seem quite easy.