Monday, 10th June 2013, 12:36 by Lasty
Ancient liches are still pretty much the most of your worries, but the other monsters are pretty nasty too. There's some strong sixfery-like melee, flayed ghosts have smite-targeted irresistible damage, deep elf necromancers are frequent, skeletal warrior bunches come with ancient champions who have strongish spells, and there's a new shadow-flame undead that's pretty nasty and heals from fire damage -- including its own fireballs. Crypt is no longer trivial.
OP, curse skulls don't regenerate quickly, so you can shoot one a few times (use portal projectile if necessary) and then back off and run around until the spawns time out. After that, you can return and finish the job. Also, if you have a Rod of Inaccuracy, it can take out the skull very quickly.