Regeneration, as onichinchin mentioned, is terribly important, which is why I went with the VSMo^Chei approach. Of course, DD of makhleb has its own take on the whole "regeneration" thing by just not doing it at all, so there's that. There are plenty of other good races for speed runs, trolls, deep elves (for casters), etc. They aren't as good, but most speed runs are judged against species high scores, or at least I say they should be.
Dive and hope for the best is enough to get you 90% of the way there. My best score is 40,133 turns for 15 runes,
here. I didn't do much other than copy the build idea, already mentioned above, of a VS with statue form and chei from other speed runners and repeat until I had one with statue form early on. Better players have done it in <20k turns (
4thArraOfDagon).
The thing is when you actually start practicing "dive and hope" you'll realize it is a lot more complex than it sounds. You're constantly deprived of resources and experience and you can't spend a large amount of time retreating and splitting up monsters, although you'll certainly have to split monsters somewhat. It's a constant tension between risk of dying and risk of playing too slowly. That's why you need an overpowered character to allow you to take more risks and progress more quickly. It's surprisingly rewarding when it's going well, although it's definitely frustrating on the dozens or hundreds of dead characters before you win. I likely won't do many speed runs in the future, although I may fire one up per year or something.